HIF-1 alpha Antibody Pack
货号：
NB100-905 基本售价：
6176.7 元 规格：
-
产品信息
概述| 货号 | NB100-905 |
| 反应种属 | Hu, MuSpecies Glossary |
| 应用 | WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP |
| 目标/特异性 | These antibodies are specific for HIF-1alpha. |
性能| 供应商 | Novus |
| 免疫原 | NB 100-654 = Human HIF-1 alpha amino acids 432-528. NB 100-105 = Human HIF-1 alpha amino acids 432-528. NB 100-131 = Human HIF-1 alpha amino acids 329-530. NB 100-449 = Human HIF-1 alpha amino acids 775-826. NB 100-479 = Mouse HIF-1 alpha amino acids |
| 背景 | Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein that activates gene transcription in response to reduced cellular 02 concentration. HIF-1 activates the transcription of EPO, VEGF, iNOS, heme oxygenase 1 and several other critical intracellular responses to hypoxia. HIF-1 is a heterodimer composed of HIF-1a and HIF-1b subunits. Both subunits are induced by hypoxia and rapidly decay upon return to normoxia and are basic-helix-loop-helix-PAS proteins. Recent research indicates the ability to regulate hypoxia-inducible factors may be related to tumor-related angiogenesis in certain cancers. |
| 存放说明 | Store at 4C. Do not freeze. |
