Human Erythropoietin MAb (Clone 9C21D11) (500 UG)【科瑞奥博】

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Human Erythropoietin MAb (Clone 9C21D11) (500 UG)

货号： MAB287-500 基本售价： 10360.6 元规格： 500 ug

产品信息

概述
货号	MAB287-500
别名	EP; EPO; epoetin; erythropoietin; MGC138142; MVCD2
反应种属	Human
应用	Neutralization
目标/特异性	Detects human Erythropoietin (Epo).
使用方法	Neutralization: Measured by its ability to neutralize Erythropoietin-induced proliferation in the TF‑1 human erythroleukemic cell line. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The Neutralization Dose (ND₅₀) is typically 0.5-1.5 µg/mL in the presence of 0.3 units/mL Recombinant Human Erythropoietin (Tissue Culture Grade).
来源	Monoclonal Mouse IgG₁ Clone # 9C21D11
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2056 (Human); 13856 (Mouse); 24335 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Authors: Kondo A, Shingo T, Yasuhara T, Kuramoto S, Kameda M, Kikuchi Y, Matsui T, Miyoshi Y, Agari T, Borlongan CV, Date I Brain Res., 2009;1296(0):127-36. Species: Rat Sample Type: In Vivo Application: In vivo
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human Erythropoietin Accession # P01588
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Erythropoietin (Epo), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Erythropoietin: Good or Bad for Cancer? HIF Transcription Factors ICC / IHC Images: Erythropoietin Protein/Peptide Hormones and Regulators Red Blood Cells (RBCs) Renal Markers

参考图片

Cell Proliferation Induced by Erythropoietin and Neutralization by Human Erythropoietin Antibody. Recombinant Human Erythropoietin (Tissue Culture Grade) (Catalog # 287-TC) stimulates proliferation in the
TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Erythropoietin (Tissue Culture Grade) (0.3 units/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Erythropoietin Monoclonal Antibody (Catalog # MAB287). The ND₅₀ is typically
0.5-1.5 µg/mL.