Ms KLRG1 NALE 2F1 500ug
货号：
562190 基本售价：
6175.0 元 规格：
500ug
产品信息
概述| 货号 | 562190 |
| 描述 | The 2F1 monoclonal antibody specifically binds to KLRG1 (Killer cell Lectin-likeReceptorG1), which is the mouse homologue of the rat mast cell function-associated antigen (MAFA),on all mouse strains tested (eg, AKR/J, BALB/c, C3H/HeN, C3H.SW, C57BL/6, DBA/1, SJL, 129/J). Unlike rat MAFA, which is expressed on mast cells, mouse KLRG1 is expressed on a large subset of NK cells, lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, subsets of activated CD8+ T lymphocytes, and small fractions of CD4+ and CD8+ T cells, but not mast cells. The expression of KLRG1 is correlated with reduced proliferative capacity of activated T lymphocytesor reduced effector functions of activated NK cells. This molecule is believed to play a common role in the regulation of leukocytes of both the innate and adaptive immune system. It has been observed that the 2F1 mAb stains the rat basophilic leukemia cell line, RBL-2H3, which is known toexpress MAFA. The KLRG1 protein is an inhibitory lectin-like type IItransmembrane receptor containing a cytoplasmic motif similar to ITIM (ImmunoreceptorTyrosine-basedInhibitoryMotif);its ligand has not beenidentified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++mobilization and cytotoxic responses (but not IFN-γ production) by CD8+ T cellsand inhibits IFN-γ and TNF-αproduction and redirected lysis by NK cells. |
| 别名 | Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA |
| 同种亚型 | Syrian Hamster IgG2, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | A-LAK from C57BL/6 mice |
| 标记 | NA/LE |
| 存放说明 | Store undiluted at 4°C.This preparation contains no preservatives, thus it should be handled under aseptic conditions.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay. |
| 浓度 | 1.0 mg/ml |
