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货号： bs-19323R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19323R
- 英文名称
- NOXO1
- 中文名称
- NADPH氧化酶调节蛋白1抗体
- 别 名
- NADPH oxidase organizer 1;NADPH oxidase regulatory protein;Nox organizer 1;Nox organizing protein 1;Nox-organizing protein 1;NOXO1;NOXO1_HUMAN;P41NOX;Regulatory protein P41NOX;SH3 and PX domain-containing protein 5;SH3PXD5.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NOXO1:1-100/376
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Function:
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Subcellular Location:
Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.Target information above from: UniProt accession Q8NFA2 The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010) .
Tissue Specificity:
Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
Similarity:
Contains 1 PX (phox homology) domain.
Contains 2 SH3 domains.
SWISS:
Q8NFA2
Gene ID:
124056
Database links:Entrez Gene: 124056Human
Entrez Gene: 71893Mouse
Entrez Gene: 302976Rat
Omim: 611256Human
SwissProt: Q8NFA2Human
SwissProt: Q8VCM2Mouse
Unigene: 191762Human
Unigene: 390971Mouse
Unigene: 137764Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.