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货号： bs-19319R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19319R
- 英文名称
- NORE1
- 中文名称
- RAP1结合蛋白抗体
- 别 名
- Maxp 1;MAXP1;MGC10823;MGC17344;New ras effector 1;NORE 1;NORE1A;NORE1B;Novel Ras effector 1;RAP1 Binding Protein;RAPL;Ras association (RalGDS/AF 6) domain family 5;Ras association (RalGDS/AF 6) domain family member 5;Ras Association (RalGDS/AF6) Domain Family 5;Ras association domain containing family protein 5;Ras association domain-containing protein 5;Ras effector like protein;RASF5_HUMAN;RASSF 3;RASSF 5;RASSF3;RASSF5;Regulator for cell adhesion and polarization enriched in lymphoid tissue;Regulator for cell adhesion and polarization enriched in lymphoid tissues;Tumor suppressor RASSF3.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Rabbit,
- 产品应用
- IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NORE1:151-250/418
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Tissue Specificity:
Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-associating domain.
Contains 1 SARAH domain.
SWISS:
Q8WWW0
Gene ID:
83593
Database links:Entrez Gene: 83593Human
Entrez Gene: 54354Mouse
Entrez Gene: 54355Rat
Omim: 607020Human
SwissProt: Q8WWW0Human
SwissProt: Q5EBH1Mouse
SwissProt: O35141Rat
Unigene: 497579Human
Unigene: 248291Mouse
Unigene: 36106Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.