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货号： bs-9546R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9546R-Cy5.5
- 英文名称
- Anti-FIBCD1/Cy5.5
- 中文名称
- Cy5.5标记的含纤维蛋白原C结构域蛋白1抗体
- 别 名
- FIBCD 1; Fibrinogen C domain containing 1; Fibrinogen C domain containing protein 1; FLJ14810; FBCD1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Zebrafish, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FIBCD1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FIBCD1 is a 461 amino acid single-pass membrane protein that contains one fibrinogen C-terminal domain and exists as multiple alternatively spliced isoforms. The gene encoding FIBCD1 maps to human chromosome 9, which contains 145 million base pairs, comprises 4% of the human genome and encodes nearly 900 genes.
Function:
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
Subunit:
Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.
Subcellular Location:
Mitochondrion matrix. Mitochondrion intermembrane space.
Isoform 1: Cytoplasm. Mitochondrion.
Isoform 2: Mitochondrion.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the sirtuin family. Class III subfamily.
Contains 1 deacetylase sirtuin-type domain.
Database links:Entrez Gene: 84929 Human
Entrez Gene: 98970 Mouse
Entrez Gene: 311861 Rat
SwissProt: Q8N539 Human
SwissProt: A2AV25 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.