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货号： bs-19225R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19225R
- 英文名称
- NFKBIL2
- 中文名称
- 核因子κB抑制蛋白样蛋白2抗体
- 别 名
- I kappa B related protein;I-kappa-B-related protein;IkappaBR;IKBR;Inhibitor of kappa B related protein;Inhibitor of kappa B-related protein;MMS22L-interacting protein;MMS22L-interacting protein, NFBIL2/TONSL;NF kappa B inhibitor like protein 2;NF-kappa-B inhibitor-like protein 2;NFBIL2;NFBIL2/TONSL;Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2;Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2;Protein IkappaBR;Tonsl;TONSL_HUMAN;Tonsoku-like protein;tonsoku-like, DNA repair protein.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat, Dog, Horse,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 175kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NFKBIL2:181-280/301
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Function:
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
Subcellular Location:
Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Tissue Specificity:
Expressed in heart, skeletal muscle and tracheal epithelial cells.
Similarity:
Belongs to the Tonsoku family.
Contains 3 ANK repeats.
Contains 7 LRR (leucine-rich) repeats.
Contains 8 TPR repeats.
SWISS:
Q96HA7
Gene ID:
4796
Database links:Entrez Gene: 505102Cow
Entrez Gene: 475127Dog
Entrez Gene: 4796Human
Entrez Gene: 72749Mouse
Entrez Gene: 366953Rat
Omim: 604546Human
SwissProt: Q0P5G1Cow
SwissProt: Q96HA7Human
SwissProt: Q6NZL6Mouse
SwissProt: D4A615Rat
Unigene: 675285Human
Unigene: 358749Mouse
Unigene: 19092Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.