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货号： bs-19223R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19223R
- 英文名称
- NFATC2IP
- 中文名称
- 活化T细胞核因子胞浆相互作用蛋白2抗体
- 别 名
- 45 kDa NF-AT-interacting protein;45 kDa NFAT-interacting protein;cytoplasmic 2-interacting protein;ESC2;NF2IP_HUMAN;NFAT-interacting protein, 45-KD;NFATC2-interacting protein;Nfatc2ip;NIP45;Nuclear factor of activated T-cells;Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein;RAD60.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 神经生物学 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Cynomolgus Monkey
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NFATC2IP:171-270/419
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohns disease, which is a gastrointestinal inflammatory condition.
Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production.
Subcellular Location:
Nucleus. Cytoplasm. TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Post-translational modifications:
Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
Similarity:
Contains 1 ubiquitin-like domain.
SWISS:
Q8NCF5
Gene ID:
84901
Database links:Entrez Gene: 84901Human
Entrez Gene: 18020Mouse
Entrez Gene: 308983Rat
Omim: 614525Human
SwissProt: Q9GLZ9 Cynomolgus Monkey
SwissProt: Q8NCF5Human
SwissProt: O09130Mouse
SwissProt: Q6AYG7Rat
Unigene: 513470Human
Unigene: 1389Mouse
Unigene: 101030Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.