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货号： bs-19190R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19190R
- 英文名称
- NEDL2
- 中文名称
- E3泛素蛋白连接酶HECW2抗体
- 别 名
- C2 and WW domain-containing protein 2;E3 ubiquitin protein ligase HECW2;E3 ubiquitin-protein ligase HECW2;HECT;HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2;Hecw2;HECW2_HUMAN;KIAA130;KIAA1301;NEDD4 like E3 ubiquitin protein ligase 2;NEDD4 Related E3 Ubiquitin Ligase;NEDD4-like E3 ubiquitin-protein ligase 2.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 表观遗传学 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 176kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NEDL2:21-120/1572
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- PubMed
- PubMed
- 产品介绍
- background:
NEDL2 is a 1,572 amino acid cytoplasmic protein that is involved in protein modification and ubiquitination and exists as two alternatively spliced isoforms. NEDL2 acts as an E3 ubiquitin-protein ligase that enhances p73 transcription activation, ubiquitination and stabilization, and is highly expressed in adult heart, lung and brain. Containing one C2 domain, two WW domains and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain, NEDL2 is encoded by a gene that maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in adult brain, lung and heart.
Similarity:
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains.
SWISS:
Q9P2P5
Gene ID:
57520
Database links:Entrez Gene: 57520Human
Entrez Gene: 329152Mouse
Entrez Gene: 100155879Pig
Entrez Gene: 316395Rat
SwissProt: Q9P2P5Human
SwissProt: Q6I6G8Mouse
Unigene: 654742Human
Unigene: 132150Mouse
Unigene: 447527Mouse
Unigene: 198842Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.