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货号： bs-19003R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19003R
- 英文名称
- NAGPA
- 中文名称
- NAGPA蛋白抗体
- 别 名
- Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA; NAGPA_HUMAN; Phosphodiester alpha-GlcNAcase.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Horse,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NAGPA:171-270/515
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as uncovering enzyme or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the proteins C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step.
Subunit:
Homotetramer arranged as two disulfide-linked homodimers
Subcellular Location:
Golgi apparatus > Golgi stack membrane. Cis/medial Golgi.
Tissue Specificity:
Isoform 2 may be brain-specific.
Post-translational modifications:
The precursor is cleaved and activated in the trans-Golgi network by a furin endopeptidase.
Similarity:
Contains 1 EGF-like domain.
SWISS:
Q9UK23
Gene ID:
51172
Database links:Entrez Gene: 515935Cow
Entrez Gene: 490019Dog
Entrez Gene: 100723215 Guinea pig
Entrez Gene: 100069983Horse
Entrez Gene: 51172Human
Entrez Gene: 27426Mouse
Entrez Gene: 100512596Pig
Entrez Gene: 360476Rat
Omim: 607985Human
SwissProt: P68827Cow
SwissProt: Q9UK23Human
SwissProt: Q8BJ48Mouse
Unigene: 21334Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.