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货号： bs-17389R-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17389R-Cy5
- 英文名称
- Anti-HS2ST1/Cy5
- 中文名称
- Cy5标记的HS2ST1蛋白抗体
- 别 名
- 2-O-sulfotransferase; 2OST; dJ604K5.2; FLJ11317; heparan sulfate 2 O sulfotransferase 1; Heparan sulfate 2-O-sulfotransferase 1; HS2ST_HUMAN; hs2st1; KIAA0448; MGC131986.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 42kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HS2ST1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Heparan sulfate structures, which are responsible for executing multiple biologic activities, are generated and regulated by heparan sulfate biosynthetic enzymes. HS2ST1 is a 356 amino acid single-pass type II membrane protein that localizes to the golgi apparatus and belongs to the sulfotransferase 3 family. Expressed as multiple alternatively spliced isoforms, HS2ST1 functions to catalyze the transfer of sulfate groups to hexuronic acid residues within maturing heparan sulfate (HS), an event which is crucial for proper HS-related ligand binding and signaling processes. HS2ST1 is subject to post-translational N-glycosylation and, in addition to its role in HS function, may be involved in proper kidney formation.
Function:
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues.
Subcellular Location:
Golgi apparatus membrane.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the sulfotransferase 3 family.
Database links:Entrez Gene: 9653Human
Entrez Gene: 23908Mouse
Entrez Gene: 292155Rat
GenBank: AA987571.1Human
SwissProt: Q7LGA3Human
SwissProt: Q8R3H7Mouse
Unigene: 137733Human
Unigene: 726055Human
Unigene: 12863Mouse
Unigene: 465667Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.