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货号： bs-17026R-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17026R-Cy5
- 英文名称
- Anti-KIAA1737/Cy5
- 中文名称
- Cy5标记的KIAA1737蛋白抗体
- 别 名
- K1737_HUMAN; KIAA1737; Uncharacterized protein KIAA1737.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KIAA1737
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
KIAA1737 is a 399 amino acid protein that is encoded by a gene that maps to human chromosome 14q24.3. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimers disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder α1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies.
Function:
Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).
Subunit:
Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Subcellular Location:
Nucleus {ECO:0000250}. Note=Co-localizes with CLOCK in the nucleus
Database links:Entrez Gene: 85457Human
SwissProt: Q9C0C6 Human
SwissProt: Q8R0W1Mouse
Unigene: 709066Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.