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货号： bs-16525R-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16525R-Cy5
- 英文名称
- Anti-ZNF675/Cy5
- 中文名称
- Cy5标记的锌指蛋白675抗体
- 别 名
- FLJ36350; TBZF; TIZ; TRAF6-binding zinc finger protein; TRAF6-inhibitory zinc finger protein; Zinc finger protein 675; ZN675_HUMAN; ZNF 675; ZNF675.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 66kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF675
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. TBZF (TRAF6-inhibitory zinc finger protein), also known as Zinc finger protein 675, is a 568 amino acid nuclear protein that contains one KRAB domain and fifteen C2H2-type zinc fingers. Through modulation of TRAF6 signaling activity and inhibition of RANK signaling, TBZF may play a role in osteoclast differentiation. TBZF is regulated during differentiation of human peripheral blood monocytes into osteoclasts and transfection of TBZF into RAW264.7 cells reduces RANK ligand-induced osteoclastogenesis.
Function:
May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
Subunit:
Interacts with TRAF6.
Subcellular Location:
Nucleus (Probable).
Similarity:
Contains 15 C2H2-type zinc fingers.
brContains 1 KRAB domain.
Database links:Entrez Gene: 171392Human
SwissProt: Q8TD23Human
Unigene: 264345Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.