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货号： bs-17499R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17499R
- 英文名称
- SIRPB2
- 中文名称
- 信号调节蛋白β2/SIRP-β2抗体
- 别 名
- BIG 3; dJ776F14.2; Protein tyrosine phosphatase non-receptor type substrate 1-like 3; Protein tyrosine phosphatase non-receptor type substrate protein; PTPNS1L3; RP4-776F14.1; Signal-regulatory protein beta-2; SIRB2_HUMAN; SIRP-beta-2; SIRPB2.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SIRPB2:31-130/342 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
SIRPs are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-kinase pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-alpha 1 is a transmembrane protein which acts as a substrate for activated receptor tyrosine kinases and, in its tyrosine phosphorylated form, binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha 1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and Insulin. SIRP-beta 1 shares extensive sequence homology with SIRP-alpha 1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-beta 2 is a 342 amino acid multi-pass membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains and exists as multiple alternatively spliced isoforms.
Subcellular Location:
Membrane.
Similarity:
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
SWISS:
Q5JXA9
Gene ID:
284759
Database links:Entrez Gene: 284759Human
SwissProt: Q5JXA9Human
Unigene: 721685Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.