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货号： bs-17462R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17462R
- 英文名称
- HJURP
- 中文名称
- HJURP蛋白抗体
- 别 名
- 14-3-3-associated AKT substrate; FAKTS; fetal liver expressing gene 1; Fetal liver-expressing gene 1 protein; FLEG1; hFLEG1; HJURP; Holliday junction recognition protein; Up-regulated in lung cancer 9; URLC9.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 84kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HJURP:21-120/748
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
HJURP is a 748 amino acid protein that is expressed in thymus, placenta, small intestine, liver, skeletal muscle, bone marrow and colon. When histone H3-like variant CENP-A nucleosomes are assembled, HJURP localizes in centromeres during late telophase and early G1 phase, and localizes to the nucleolus during S phase. Considered a centromeric protein, HJURP plays a central role in the incorporation and maintenance of CENP-A at centromeres. HJURP also acts as a specific chaperone for CENP-A and is required for the incorporation of newly synthesized CENP-A molecules into nucleosomes at replicated centromeres. HJURP is considered an indispensable factor for chromosomal stability in immortalized cancer cells and is a potential novel therapeutic target for the development of anticancer drugs.
Function:
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.
Subcellular Location:
Nucleus; nucleolus. Centromere. Note: Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
SWISS:
Q8NCD3
Gene ID:
55355
Database links:Entrez Gene: 55355Human
Omim: 612667Human
SwissProt: Q8NCD3Human
Unigene: 532968Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.