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货号： bs-17450R 基本售价： 1580.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17450R
- 英文名称
- phospho-Histone H4 (Thr31)
- 中文名称
- 磷酸化组蛋白H4抗体
- 别 名
- Histone H4 (phospho T30); phospho-Histone H4 (Thr31); p-Histone H4 (phospho T30); H4F2; H4FN; HIST1H4; HIST2H4; HISTH4H4; methyl histone H4; histone H4; H4_HUMAN; Osteogenic growth peptide; OGP.
- 规格价格
- 100ul/1580元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Chicken, Dog, Cow,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 11kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human Histone H4 around the phosphorylation site of Thr31:QGI(p-T)KP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008]
Function:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Linker histones are involved in the formation of higher order structure in chromatin and the maintenance of overall chromatin compaction. Whilst the core histones are highly conserved across a wide range of organisms, the linker histones are less conserved. Histones can be post-translationally modified by methylation, phosphorylation, acetylation, citrullination and/or biotinylated. There is no current data to demonstrate that histones are hydroxylated. This antibody was raised against a previously unidentified and novel histone modification and feedback on the modification is appreciated.
Subcellular Location:
Nuclear.
Post-translational modifications:
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
Similarity:
Belongs to the histone H4 family.
SWISS:
P02304
Gene ID:
121504
Database links:Entrez Gene: 121504Human
Entrez Gene: 554313Human
Entrez Gene: 8294Human
Entrez Gene: 8359Human
Entrez Gene: 8360Human
Entrez Gene: 8361Human
Entrez Gene: 8362Human
Entrez Gene: 8363Human
Entrez Gene: 8364Human
Entrez Gene: 8365Human
Entrez Gene: 8366Human
Entrez Gene: 8367Human
Entrez Gene: 8368Human
Entrez Gene: 8370Human
Entrez Gene: 100041230Mouse
Entrez Gene: 100862646Mouse
Entrez Gene: 319155Mouse
Entrez Gene: 319156Mouse
Entrez Gene: 319157Mouse
Entrez Gene: 319158Mouse
Entrez Gene: 319159Mouse
Entrez Gene: 319160Mouse
Entrez Gene: 319161Mouse
Entrez Gene: 320332Mouse
Entrez Gene: 326619Mouse
Entrez Gene: 326620Mouse
Entrez Gene: 69386Mouse
Entrez Gene: 97122Mouse
GenBank: NM_003548Human
Omim: 142750Human
SwissProt: P84040 Fruit fly (Drosophila melanogaster)
SwissProt: P02304Human
SwissProt: P62805Human
SwissProt: P02304Mouse
SwissProt: P62806Mouse
SwissProt: P02304Rat
SwissProt: P09322 Schizosaccharomyces pombe
Unigene: 21500 Fruit fly (Drosophila melanogaster)
Unigene: 29514 Fruit fly (Drosophila melanogaster)
Unigene: 29527 Fruit fly (Drosophila melanogaster)
Unigene: 30219 Fruit fly (Drosophila melanogaster)
Unigene: 30220 Fruit fly (Drosophila melanogaster)
Unigene: 30221 Fruit fly (Drosophila melanogaster)
Unigene: 30223 Fruit fly (Drosophila melanogaster)
Unigene: 30868 Fruit fly (Drosophila melanogaster)
Unigene: 30869 Fruit fly (Drosophila melanogaster)
Unigene: 30871 Fruit fly (Drosophila melanogaster)
Unigene: 30872 Fruit fly (Drosophila melanogaster)
Unigene: 30873 Fruit fly (Drosophila melanogaster)
Unigene: 30876 Fruit fly (Drosophila melanogaster)
Unigene: 33873 Fruit fly (Drosophila melanogaster)
Unigene: 5747 Fruit fly (Drosophila melanogaster)
Unigene: 143080Human
Unigene: 247816Human
Unigene: 248172Human
Unigene: 248178Human
Unigene: 248179Human
Unigene: 278483Human
Unigene: 352191Human
Unigene: 46423Human
Unigene: 528055Human
Unigene: 533295Human
Unigene: 55468Human
Unigene: 591790Human
Unigene: 655235Human
Unigene: 662174Human
Unigene: 706635Human
Unigene: 742244Human
Unigene: 14775Mouse
Unigene: 158272Mouse
Unigene: 227295Mouse
Unigene: 228709Mouse
Unigene: 246720Mouse
Unigene: 255646Mouse
Unigene: 260530Mouse
Unigene: 261642Mouse
Unigene: 261662Mouse
Unigene: 261664Mouse
Unigene: 377875Mouse
Unigene: 442307Mouse
Unigene: 486099Mouse
Unigene: 489077Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.