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货号： bs-17425R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17425R
- 英文名称
- Histone H2A.V
- 中文名称
- 组蛋白H2家族A.V抗体
- 别 名
- H2A.F/Z; h2afv; H2AV; H2AV_HUMAN; Histone H2A.V.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 表观遗传学 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Xenopus laevis
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Histone H2A.V:21-80/128
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms a heterodimer with H2B (By similarity).
Subcellular Location:
Nucleus. Chromosome.
Post-translational modifications:
Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Similarity:
Belongs to the histone H2A family.
SWISS:
Q71UI9
Gene ID:
94239
Database links:Entrez Gene: 613618Cow
Entrez Gene: 94239Human
Entrez Gene: 77605Mouse
Entrez Gene: 100328558Rabbit
Entrez Gene: 444541 Xenopus laevis
Entrez Gene: 548932 Xenopus tropicalis
Entrez Gene: 252913Zebrafish
SwissProt: Q32LA7Cow
SwissProt: Q71UI9Human
SwissProt: Q3THW5Mouse
SwissProt: O62695Rabbit
SwissProt: Q6GM74 Xenopus laevis
SwissProt: Q5BJ65 Xenopus tropicalis
SwissProt: Q71PD7Zebrafish
Unigene: 488189Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.