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货号： bs-17374R 基本售价： 1580.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17374R
- 英文名称
- phospho-HP1 gamma (Ser83)
- 中文名称
- 磷酸化染色质相关蛋白1-γ抗体
- 别 名
- HP1 gamma (phospho S83); p-HP1 gamma (phospho S83); CBX 3; CBX3; CBX3_HUMAN; Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3; Chromobox protein homolog 3; GAMMA; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; Heterochromatin protein HP1 gamma; HP1 gamma; HP1 gamma homolog; HP1 gamma homolog; HP1Hs gamma; HP1Hs gamma; Modifier 2 protein; Modifier 2 protein; S83. HP-1-γ; HP 1γ; HP-1γ; HP-1 γ; HP1γ; HP1 γ;
- 规格价格
- 100ul/1580元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rhesus monkey
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human HP1 gamma around the phosphorylation site of Ser83:
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Function:
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Subcellular Location:
Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
Post-translational modifications:
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Similarity:
Contains 2 chromo domains.
SWISS:
Q13185
Gene ID:
11335
Database links:Entrez Gene: 539788Cow
Entrez Gene: 11335Human
Entrez Gene: 12417Mouse
Entrez Gene: 706978 Rhesus monkey
Omim: 604477Human
SwissProt: Q13185Human
SwissProt: P23198Mouse
SwissProt: Q5R6X7Orangutan
Unigene: 381189Human
Unigene: 280968Mouse
Unigene: 458234Mouse
Unigene: 485141Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.