产品中心
当前位置：首页>产品中心Anti-JIK/TAOK3
货号： bs-17202R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17202R
- 英文名称
- JIK/TAOK3
- 中文名称
- JNK/ SAPK抑制激酶抗体
- 别 名
- CTCL tumor antigen HD CL 09; CTCL-associated antigen HD-CL-09; Cutaneous T cell lymphoma tumor antigen HD CL 09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell derived protein kinase; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC A; hKFC-A; JIK; JNK/SAPK inhibitory kinase; JNK/SAPK-inhibitory kinase; Jun kinase inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine kinase; Serine/threonine-protein kinase TAO3; STE20 like kinase; TAO kinase 3; TAOK3; TAOK3_HUMAN; Thousand and one amino acid protein 3.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 激酶和磷酸酶 淋巴细胞 t-淋巴细胞 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 105kDa
- 细胞定位
- 细胞浆 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human JIK:501-600/898
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear.
Function:
Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.
Subcellular Location:
Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane.
Tissue Specificity:
Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
Post-translational modifications:
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.
SWISS:
Q9H2K8
Gene ID:
51347
Database links:Entrez Gene: 51347Human
Entrez Gene: 330177Mouse
Entrez Gene: 100174000Orangutan
Entrez Gene: 304530Rat
Entrez Gene: 446778 Xenopus laevis
SwissProt: Q9H2K8Human
SwissProt: Q9HC79Human
SwissProt: Q8BYC6Mouse
SwissProt: Q5R4F3Orangutan
SwissProt: Q53UA7Rat
SwissProt: Q6DD27 Xenopus laevis
Unigene: 644420Human
Unigene: 24343Mouse
Unigene: 248296Mouse
Unigene: 162145Rat
Unigene: 27040 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.