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货号： bs-17140R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-17140R
- 英文名称
- TRIO
- 中文名称
- TRIO蛋白抗体
- 别 名
- ARHGEF23; PTPRF-interacting protein; tgat; trio; TRIO_HUMAN; Triple functional domain protein.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 347kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRIO:401-500/3097
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane-associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPa, PTPb, PTPg, PTPd, PTPe, PTPz, PTPk and PTPm. Transmembrane PTPs play diverse roles during development and in adult tissues. Immunodepletion studies have suggested LAR to be a regulator of insulin receptor phosphorylation. Trio is a LAR-interacting protein that contains two functional guanine nuclear exchange factor (GEF) domains and a serine/threonine protein kinase (PSK) domain. One of the the Trio-GEF domains exhibits Rac-specific GEF activity while the other exibits Rho-specific GEF activity. The carboxy terminal PSK domain is most similar to the PSK domains of the CaMK family.
Function:
Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
Subunit:
Interacts to form a complex with leukocyte antigen related protein.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.
Post-translational modifications:
Phosphorylated on serine residue(s).
Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
Contains 1 CRAL-TRIO domain.
Contains 2 DH (DBL-homology) domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 PH domains.
Contains 1 protein kinase domain.
Contains 2 SH3 domains.
Contains 4 spectrin repeats.
SWISS:
O75962
Gene ID:
7204
Database links:Entrez Gene: 7204Human
Omim: 601893Human
SwissProt: O75962Human
Unigene: 130031Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.