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货号： bs-16653R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-16653R
- 英文名称
- ING2
- 中文名称
- 肿瘤生长抑制蛋白2抗体
- 别 名
- ING 1 like tumor suppressor protein; ING 1L; ING 2; ING1 like tumor suppressor protein; ING1L; ING1Lp; ING2; ING2_HUMAN; Inhibitor of growth 1 like; Inhibitor of growth 1 like protein; Inhibitor of growth 1-like protein; Inhibitor of growth family member 1 like; Inhibitor of growth family member 2; Inhibitor of growth protein 2; p32; p33 ING2; p33ING2.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 33kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ING2:151-250/280
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
Function:
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Subcellular Location:
Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
Tissue Specificity:
Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.
SWISS:
Q9H160
Gene ID:
3622
Database links:Entrez Gene: 3622Human
Entrez Gene: 69260Mouse
Entrez Gene: 290744Rat
Omim: 604215Human
SwissProt: Q9H160Human
SwissProt: Q9ESK4Mouse
Unigene: 107153Human
Unigene: 430733Mouse
Unigene: 20482Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.