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货号： bs-16323R 基本售价： 1580.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16323R
- 英文名称
- phospho-GRLF1 (Tyr1105)
- 中文名称
- 磷酸化糖皮质激素受体DNA结合因子1抗体
- 别 名
- GRLF1 (phospho Y1105); p-GRLF1 (phospho Tyr1105); ARHGAP35; GAP associated protein p190; Glucocorticoid receptor DNA binding factor 1; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; Glucocorticoid receptor repression factor 1; GRF 1; GRF-1; GRF1; GRLF 1; GRLF1; GRLF1_HUMAN; KIAA1722; MGC10745; p190 A; p190-A; P190A; P190A, rat, homolog of; p190ARhoGAP; p190RhoGAP; Rho GAP p190A; Rho GAP p190A; Rho GTPase-activating protein 35.
- 规格价格
- 100ul/1580元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 171kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human GRLF1 around the phosphorylation site of Tyr1105:NI(p-Y)SV
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
Function:
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5-GAGAAAAGAAACTGGAGAAACTC-3. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.
Subcellular Location:
Cytoplasm. Nucleus.
Post-translational modifications:
Tyrosine phosphorylated.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 4 FF domains.
Contains 1 Rho-GAP domain.
SWISS:
Q9NRY4
Gene ID:
2909
Database links:Entrez Gene: 2909Human
Entrez Gene: 232906Mouse
Entrez Gene: 306400Rat
Omim: 605277Human
SwissProt: Q9NRY4Human
SwissProt: Q91YM2Mouse
SwissProt: P81128Rat
Unigene: 509447Human
Unigene: 28646Mouse
Unigene: 400358Mouse
Unigene: 16508Rat
Unigene: 222475Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.