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货号： bs-16253R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-16253R
- 英文名称
- GLCE
- 中文名称
- 葡萄糖醛酸差向异构酶抗体
- 别 名
- Glucuronic Acid Epimerase;D glucuronyl C5 epimerase; GLCE; GLCE_HUMAN;Heparin/heparan sulfate:glucuronic acid C5 epimerase; HSEPI; KIAA0836.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 70kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GLCE:541-617/617
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
GLCE (glucuronic acid epimerase), also known as HSEPI (heparin/heparan sulfate:glucuronic acid C5-epimerase) or D-glucuronyl C5-epimerase, is a single-pass type II membrane protein that is part of the golgi apparatus and, through its enzymatic activity, is essential for proper biological function of heparan sulphate (HS). GLCE epimerizes D-glucuronic acid into L-iduronic acid of HS, thus changing the specificity of HS and allowing it to bind to cytokines and growth factors. GLCE is a target of the beta-catenin–TCF4 transactivation complex; an essential component in the Wnt/APC/beta-catenin signaling pathway that is upregulated in colon carcinoma cells. The enzymatic activity of GLCE is enhanced by overexpression of beta-catenin–TCF4, suggesting a possible role for GLCE in the dysregulation of proper signaling pathways; a dysregulation that leads to the development of human epithelial tumors.
Function:
Glucuronic Acid Epimerase (GLCE) is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of Heparan sulfate (HS), which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).
Subunit:
Interacts with HS2ST1 (By similarity).
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein
Similarity:
Belongs to the D-glucuronyl C5-epimerase family.
SWISS:
O94923
Gene ID:
26035
Database links:Entrez Gene: 26035Human
Entrez Gene: 93683Mouse
Omim: 612134Human
SwissProt: O94923Human
SwissProt: Q9EPS3Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.