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货号： bs-16244R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-16244R
- 英文名称
- GIGYF1
- 中文名称
- PERQ1蛋白抗体
- 别 名
- CDS2; GIGYF1; GRB10-interacting GYF protein 1; GYF1; PERQ amino acid-rich with GYF domain-containing protein 1; PERQ1; PERQ1_HUMAN; Postmeiotic segregation increased 2-like 12; PP3360.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 115kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GIGYF1:31-130/1035
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
PERQ1 is a 1,035 amino acid phosphoprotein that contains one GYF domain and belongs to the PERQ family. Ubiquitously expressed, PERQ1 exhibits highest expression in brain and lung, followed by heart, spleen and kidney. PERQ1 contains a GYF domain in its N-terminal half and a clathrin light chain homology domain in its C-terminal half. PERQ1 interacts with GRB10, with transient binding increased under IGF-I stimulation, thereby leading to recruitment of the PERQ1/GRB10 complex to the IGF-I receptor. PERQ1 may also increase IRS-1, Shc and IGF-I receptor phosphorylation during IGF-I stimulation, and may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling.
Function:
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1.
Similarity:
Belongs to the PERQ family.
Contains 1 GYF domain.
SWISS:
O75420
Gene ID:
64599
Database links:Entrez Gene: 64599Human
Omim: 612064Human
SwissProt: O75420Human
Unigene: 414396Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.