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货号： bs-16107R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-16107R
- 英文名称
- FLJ14213
- 中文名称
- Protor2蛋白抗体
- 别 名
- FLJ14213 protein; Hypothetical protein FLJ14213; Hypothetical protein LOC79899; Proline-rich protein 5-like; Protein observed with Rictor-2; Protor 2; Protor-2; PROTOR2; PRR5L; PRR5L_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FLJ14213:231-330/368
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
mTOR is a large protein kinase that is important in cell growth and functions as the mammalian target of Rapamycin, an immunosuppressant that blocks vessel restenosis and also has potential anticancer applications. Rapamycin-insensitive companion of mTOR, also designated Rictor, forms a complex (designated mTORC2) with mTOR that directly phosphorylates Akt/PKB on Ser473 and plays a key role in growth signaling pathways. Protor-2, also known as PROTOR2 or FLJ14213, is a 368 amino acid protein that is thought to interact with the mTORC2 complex and, via this interaction, may regulate organization of the Actin cytoskeleton. Three isoforms of Protor-2 are expressed due to alternative splicing events.
Function:
May be part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Subunit:
Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL.
Post-translational modifications:
Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
Similarity:
Belongs to the PROTOR family.
SWISS:
Q6MZQ0
Gene ID:
79899
Database links:Entrez Gene: 79899Human
Entrez Gene: 505048Cow
Entrez Gene: 72446Mouse
Entrez Gene: 362171Rat
Omim: 611728Human
SwissProt: Q6MZQ0Human
SwissProt: A2AVJ5Mouse
SwissProt: A1L1K1Rat
Unigene: 19987Human
Unigene: 24138Mouse
Unigene: 19060Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.