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货号： bs-12644R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12644R-Cy3
- 英文名称
- Anti-SMTNL1/Cy3
- 中文名称
- Cy3标记的平滑肌样蛋白1抗
- 别 名
- Calponin homology associated smooth muscle protein; CHASM; OTTHUMP00000235021; Smoothelin like 1; Smoothelin like protein 1; SMTNL1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转录调节因子 细胞骨架 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SMTNL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010]
Function:
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).
Subcellular Location:
Cytoplasm ?myofibril. Cytoplasm ?myofibril ?sarcomere ?I band By similarity. Cytoplasm ?myofibril ?sarcomere ?M line. Nucleus. Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus,
Tissue Specificity:
Expressed in striated muscles, specifically in type 2a fibers (at protein level).
Post-translational modifications:
Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.
Similarity:
Belongs to the smoothelin family.
Contains 1 CH (calponin-homology) domain.
Database links:Entrez Gene: 219537Human
Omim: 613664Human
SwissProt: A8MU46Human
Unigene: 68756Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.