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货号： bs-10986R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10986R-Cy3
- 英文名称
- Anti-Somatostatin Receptor 2/Cy3
- 中文名称
- Cy3标记的生长抑素受体2抗体
- 别 名
- somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 发育生物学 神经生物学 细胞凋亡 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Somatostatin Receptor 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively.
Function:
Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
Subunit:
The C-terminus interacts with SHANK1 PDZ domain.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 6752Human
Entrez Gene: 20606Mouse
Entrez Gene: 54305Rat
Omim: 182452Human
SwissProt: P30874Human
SwissProt: P30875Mouse
SwissProt: P30680Rat
Unigene: 514451Human
Unigene: 454968Mouse
Unigene: 202974Rat
Unigene: 9929Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.