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货号： bs-19226R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19226R-Cy3
- 英文名称
- Anti-NFRKB/Cy3
- 中文名称
- Cy3标记的DNA结合蛋白κB抗体
- 别 名
- A530090G11Rik; DKFZp547B2013; DNA binding protein R kappa B; INO80 complex subunit G; INO80G; Nuclear factor related to kappa B binding protein; Nuclear factor related to kappaB binding protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 139kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NFRKB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DNA-binding protein R kappa-B, is a nuclear protein that binds to the DNA consensus sequence 5-GGGGAATCTCC-3 of NF kappa B. Binding of NFR kappa B is thought to regulate IL-2R alpha (interleukin-2 receptor alpha-chain) gene expression, a critical step in T-cell activation. NFR kappa B exists as 3 isoforms due to alternative splicing and is expressed primarily in the brain, liver, spleen, testis and thymus NFR kappa B gene expression is amplified in acute myeloid leukemia, suggesting a possible role in carcinogenesis.
Function:
Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
Subcellular Location:
Nuclear
Tissue Specificity:
Expressed in thymus, brain, testes, spleen and liver.
Database links:Entrez Gene: 419727Chicken
Entrez Gene: 419730Chicken
Entrez Gene: 4798Human
Entrez Gene: 235134Mouse
Entrez Gene: 315523Rat
Omim: 164013Human
SwissProt: Q6P4R8Human
SwissProt: Q6PIJ4Mouse
Unigene: 530539Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.