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货号： bs-19192R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19192R-Cy3
- 英文名称
- Anti-NEIL1/Cy3
- 中文名称
- Cy3标记的核酸内切酶8样蛋白1抗体
- 别 名
- DNA (apurinic or apyrimidinic site) lyase Neil1;DNA glycosylase/AP lyase Neil 1;DNA glycosylase/AP lyase Neil1;DNA-(apurinic or apyrimidinic site) lyase Neil1;Endonuclease 8 like 1;Endonuclease 8-like 1;endonuclease VIII;Endonuclease VIII like 1;Endonuclease VIII-like 1;FLJ22402;FPG1;hFPG1;NEH 1;NEH1;NEI 1;Nei endonuclease VIII like 1 (E. coli);nei endonuclease VIII like 1;Nei endonuclease VIII like 1;Nei homolog 1;Nei like 1;Nei like protein 1;Nei-like protein 1;NEI1;NEIL 1;Neil1;NEIL1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NEIL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the FPG family.
Database links:Entrez Gene: 79661Human
Entrez Gene: 72774Mouse
Omim: 608844Human
SwissProt: Q96FI4Human
SwissProt: Q8K4Q6Mouse
Unigene: 512732Human
Unigene: 35749Mouse
Unigene: 438037Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.