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货号： bs-19159R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19159R-Cy3
- 英文名称
- Anti-ZFYVE26/Cy3
- 中文名称
- Cy3标记的锌指蛋白结构域ZFYVE26抗体
- 别 名
- DKFZp686F19106; DKFZp781H1112; FYVE domain-containing centrosomal protein; FYVE-CENT; KIAA0321; Spastic paraplegia 15 (complicated autosomal recessive); Spastizin; SPG15; ZFY26_HUMAN; ZFYVE 26; ZFYVE26; Zinc finger FYVE domain containing 26; Zinc finger FYVE domain containing protein 26; Zinc finger FYVE domain-containing protein 26.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 锌指蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 285kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZFYVE26
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Function:
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
Subcellular Location:
Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Midbody. Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
Tissue Specificity:
Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.
DISEASE:
Spastic paraplegia 15, autosomal recessive
Similarity:
Contains 1 FYVE-type zinc finger.
Database links:Entrez Gene: 514402Cow
Entrez Gene: 23503Human
Entrez Gene: 211978Mouse
Entrez Gene: 314265Rat
Omim: 612012Human
SwissProt: E1BLZ4Cow
SwissProt: Q68DK2Human
SwissProt: Q5DU37Mouse
SwissProt: D4A8G9Rat
Unigene: 98041Human
Unigene: 297919Mouse
Unigene: 16048Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.