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货号： bs-18760R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18760R-Cy3
- 英文名称
- Anti-MECR/Cy3
- 中文名称
- Cy3标记的核受体结合因子MECR抗体
- 别 名
- AI195831; CGI 63; FASN2B; Homolog of yeast 2 enoyl thioester reductase; HsNrbf-1; HsNrbf1; mecr; MECR_HUMAN; Mitochondrial 2 enoyl thioester reductase; mitochondrial; NRBF 1; NRBF-1; NRBF1; Nuclear receptor binding factor 1; Nuclear receptor-binding factor 1; OTTMUSP00000009996; RP23-13A13.1; Trans 2 enoyl CoA reductase, mitochondrial; Trans-2-enoyl-CoA reductase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MECR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Mecr is a 373 amino acid mitochondrial protein that may play a role in fatty acid synthesis. Existing as two alternatively spliced isoforms, Mecr is highly expressed in cardiac and skeletal muscle, with lower levels found in pancreas, kidney, placenta and liver. Mecr forms a homodimer and belongs to the zinc-containing alcohol dehydrogenase family and quinone oxidoreductase subfamily. Mecr reduces trans-2-enoyl-CoA to acyl-CoA in an NADPH-dependent manner and is encoded by a gene that maps to human chromosome 1p35.3. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.
Function:
Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.
Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family.
Quinone oxidoreductase subfamily.
Database links:Entrez Gene: 51102Human
Entrez Gene: 26922Mouse
Entrez Gene: 29470Rat
Omim: 608205Human
SwissProt: Q9BV79Human
SwissProt: Q9DCS3Mouse
SwissProt: Q9Z311Rat
Unigene: 183646Human
Unigene: 192706Mouse
Unigene: 15375Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.