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货号： bs-10987R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10987R-Cy3
- 英文名称
- Anti-RRAGB/Cy3
- 中文名称
- Cy3标记的RAS相关GTP结合蛋白B抗体
- 别 名
- GTP-binding protein ragB; Rag B; RagB; Ras-related GTP-binding protein B; RRAGB; RRAGB_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 染色质和核信号 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RRAGB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.
Subunit:
Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins. In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR.
Subcellular Location:
Cytoplasm. Lysosome.
Similarity:
Belongs to the GTR/RAG GTP-binding protein family.
Database links:Entrez Gene: 506754 Cow
Entrez Gene: 10325 Human
Entrez Gene: 491907 Dog
Entrez Gene: 100724885 Guinea pig
Entrez Gene: 100629499 Horse
Entrez Gene: 245670 Mouse
Entrez Gene: 100346402 Rabbit
Entrez Gene: 100909655 Rat
Entrez Gene: 117043 Rat
Entrez Gene: 101107847 Sheep
Entrez Gene: 325358 Zebrafish
Omim: 300725 Human
SwissProt: Q5VZM2 Human
SwissProt: Q6NTA4 Mouse
SwissProt: Q63487 Rat
Unigene: 50282 Human
Unigene: 190922 Mouse
Unigene: 203382 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.