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货号： bs-14475R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-14475R
- 英文名称
- FXYD5/Dysadherin
- 中文名称
- 抗粘附素抗体
- 别 名
- Dysad; Dysadherin; FXYD 5; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; Fxyd5; FXYD5_HUMAN; FXYD5RIC; HSPC 113; HSPC113; IWU 1; IWU1; KCT 1; KCT1; Keratinocytes associated transmembrane protein 1; OIT 2; OIT2; PRO 6241; PRO6241; RIC.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 细胞粘附分子 肿瘤细胞生物标志物 跨膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Dysadherin:21-120/178 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J.
Function:
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
Subcellular Location:
Membrane.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the FXYD family.
SWISS:
Q96DB9
Gene ID:
53827
Database links:Entrez Gene: 53827Human
GenBank: NP_054883Human
Omim: 606669Human
SwissProt: Q96DB9Human
Unigene: 333418Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.