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货号： bs-18168R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18168R-Cy3
- 英文名称
- Anti-Tollip/Cy3
- 中文名称
- Cy3标记的Toll蛋白相互作用蛋白抗体
- 别 名
- Adapter protein; FLJ33531; IL 1RAcPIP; IL1RAcPIP; TOLIP; TOLIP_HUMAN; Toll interacting protein; Toll-interacting protein; tollip.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Xenopus laevis
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 30kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Tollip
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]
Function:
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
Similarity:
Belongs to the tollip family.
Contains 1 C2 domain.
Contains 1 CUE domain.
Database links:Entrez Gene: 54472Human
Entrez Gene: 423099Chicken
Entrez Gene: 539480Cow
Entrez Gene: 54473Mouse
Entrez Gene: 361677Rat
Entrez Gene: 336876Zebrafish
Omim: 606277Human
SwissProt: Q5ZK05Chicken
SwissProt: Q2LGB5Cow
SwissProt: Q9H0E2Human
SwissProt: Q9QZ06Mouse
SwissProt: A2RUW1Rat
SwissProt: Q7ZV43Zebrafish
Unigene: 368527Human
Unigene: 103551Mouse
Unigene: 137040Rat
Unigene: 79855Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.