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货号： bs-18162R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18162R-Cy3
- 英文名称
- Anti-TNS4/Cy3
- 中文名称
- Cy3标记的张力蛋白4抗体
- 别 名
- C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 细胞粘附分子 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TNS4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a role in tumor suppression
Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
Subcellular Location:
Cell junction > focal adhesion. Cytoplasm >cytoskeleton.
Tissue Specificity:
Prostate and placenta. Down regulated in prostate cancer.
Post-translational modifications:
Proteolytically cleaved by caspase-3 during apoptosis.
Similarity:
Contains 1 phosphatase tensin-type domain.
Contains 1 SH2 domain.
Database links:Entrez Gene: 84951Human
Entrez Gene: 217169Mouse
Omim: 608385Human
SwissProt: Q8IZW8Human
SwissProt: Q8BZ33Mouse
Unigene: 438292Human
Unigene: 262067Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.