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货号： bs-18068R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18068R-Cy3
- 英文名称
- Anti-Histone H2B K/Cy3
- 中文名称
- Cy3标记的组蛋白H2B K抗体
- 别 名
- H2B histone family member T; H2B K; H2B/S; H2BFAiii; H2BFT; HIRA-interacting protein 1; HIRIP1; HIST1H2BK; Histone family member; Histone H2B type 1-K.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Histone H2B K
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The H2bk gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, and nucleosome remodeling.
Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Subcellular Location:
Nuclear
Similarity:
Belongs to the histone H2B family.
Database links:Clone ID: BC000893Human
Entrez Gene: 616627Cow
Entrez Gene: 85236Human
Entrez Gene: 319184Mouse
IMAGE Id: 3463930Human
SwissProt: Q2M2T1Cow
SwissProt: O60814Human
SwissProt: Q8CGP1Mouse
Unigene: 88561Cow
Unigene: 247817Human
Unigene: 358955Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.