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货号： bs-14446R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-14446R
- 英文名称
- DUS1L
- 中文名称
- DUS1L蛋白抗体
- 别 名
- 1110032N12Rik; dihydrouridine synthase 1 like (S. cerevisiae); DUS1; DUS1L; DUS1L_HUMAN; PP3111; PP3111 protein; RP23-99M13.5; tRNA-dihydrouridine synthase 1-like.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DUS1L:351-450/473
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
DUS1L is a 473 amino acid protein belonging to the DUS family and DUS1 subfamily that catalyzes the synthesis of dihydrouridine, a modified base located in the D-loop of many tRNAs. DUS1L binds FAD as a cofactor and is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Similarity:
Belongs to the dus family. Dus1 subfamily.
SWISS:
Q6P1R4
Gene ID:
64118
Database links:Entrez Gene: 64118Human
Entrez Gene: 68730Mouse
Entrez Gene: 246185Rat
SwissProt: Q6P1R4Human
SwissProt: Q8C2P3Mouse
SwissProt: Q8K582Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.