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货号： bs-16762R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16762R-Cy3
- 英文名称
- Anti-KLHDC8B/Cy3
- 中文名称
- Cy3标记的KLHDC8B蛋白抗体
- 别 名
- FLJ11302; FP17659; Kelch domain containing 8B; Kelch domain containing protein 8B; Kelch domain-containing protein 8B; KLD8B_HUMAN; Klhdc8b; MGC35097; MGC94736.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KLHDC8B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
Subcellular Location:
Cytoplasm. In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.
DISEASE:
Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL) [MIM:236000]. A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. Note=A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).
Similarity:
Contains 8 Kelch repeats.
Database links:Entrez Gene: 200942Human
Entrez Gene: 78267Mouse
Entrez Gene: 306589Rat
Omim: 613169Human
SwissProt: Q8IXV7Human
SwissProt: Q9D2D9Mouse
SwissProt: Q5XIA9Rat
Unigene: 13781Human
Unigene: 283194Mouse
Unigene: 41577Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.