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货号： bs-16310R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16310R-Cy3
- 英文名称
- Anti-Granuphilin/SYTL4/Cy3
- 中文名称
- Cy3标记的突触结合蛋白样蛋白4抗体
- 别 名
- DKFZp451P0116; Exophilin-2; FLJ40960; Granuphilin; SLP4; Synaptotagmin like 4; Synaptotagmin-like protein 4; Sytl4; SYTL4_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 76kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Granuphilin/SYTL4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.
Subunit:
Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).
Subcellular Location:
Membrane. Cell membrane. Cytoplasmic vesicle > secretory vesicle membrane. Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
Similarity:
Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain.
Database links:Entrez Gene: 94121Human
Entrez Gene: 27359Mouse
Entrez Gene: 140594Rat
Omim: 300723Human
SwissProt: Q96C24Human
SwissProt: Q9R0Q1Mouse
SwissProt: Q8VHQ7Rat
Unigene: 592224Human
Unigene: 38674Mouse
Unigene: 107417Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.