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货号： bs-14221R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-14221R
- 英文名称
- DDHD1
- 中文名称
- 磷脂酶DDHD1抗体
- 别 名
- DDHD domain containing 1; DDHD domain containing protein 1; KIAA1705; PA-PLA1; PAPLA1; Phosphatidic acid-preferring phospholipase A1 homolog; Phospholipase DDHD1; Spastic paraplegia 28 (autosomal recessive); SPG28.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 100kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DDHD1:751-850/900
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Phosphatidic acid is released following cell activation and functions as a second messenger in several signaling pathways. DDHD1 is a lipase that catalyzes degradation of phosphatidic acid and attenuates cell activation.
Function:
Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity.
Subunit:
Forms homooligomers and, to a much smaller extent, heterooligomers with DDHD2.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Highly expressed in testis. Also expressed in brain, spleen and lung. Only expressed in cerebellum in fetal brain.
DISEASE:
Spastic paraplegia 28, autosomal recessive (SPG28) [MIM:609340]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Some SPG28 patients also have distal sensory impairment. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the PA-PLA1 family.
Contains 1 DDHD domain.
SWISS:
Q8NEL9
Gene ID:
80821
Database links:Entrez Gene: 80821Human
Entrez Gene: 114874Mouse
Entrez Gene: 305816Rat
Omim: 614603Human
SwissProt: Q8NEL9Human
SwissProt: Q80YA3Mouse
Unigene: 125525Human
Unigene: 121918Mouse
Unigene: 163271Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.