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货号： bs-16103R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16103R-Cy3
- 英文名称
- Anti-ZNF649/Cy3
- 中文名称
- Cy3标记的锌指蛋白649抗体
- 别 名
- FLJ12644;Zinc finger protein 649; ZN649_HUMAN; ZNF649.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 58kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF649
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 649 (ZNF649) is a 505 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF649 is highly expressed in heart, brain and skeletal muscle with lower levels of expression in lung, liver, kidney and pancreas. ZNF649 contains ten C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional repression of mitogen-activated protein kinase signaling pathways.
Function:
Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 10 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Database links:Entrez Gene: 65251Human
Omim: 611903Human
SwissProt: Q9BS31Human
Unigene: 148322Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.