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货号： bs-14174R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-14174R
- 英文名称
- Cytochrome P450 1A1 + 1A2
- 中文名称
- 细胞色素P450 1A1+1A2抗体
- 别 名
- Aryl hydrocarbon hydroxylase; CP11; CP12; CYP1A1; CYP1A2; CYPIA1; CP1A1_HUMAN; CYPIA2; CP1A2_HUMAN; Cytochrome P450 family 1 subfamily A polypeptide 1; Cytochrome P450 family 1 subfamily A polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; P1 450; P3 450; P450 form 4; P450 form 6; P450 P1; P450 P3.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 58kDa
- 细胞定位
- 细胞浆 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cytochrome P450 1A1 + 1A2:61-160/512
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
Function:
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.
Subcellular Location:
Endoplasmic reticulum
Tissue Specificity:
Lung, lymphocytes and placenta.
Similarity:
Belongs to the cytochrome P450 family.
SWISS:
P04798/P05177
Gene ID:
1543/1544
Database links:Entrez Gene: 1543Human
Entrez Gene: 1544Human
Entrez Gene: 13076Mouse
Entrez Gene: 13077Mouse
Entrez Gene: 24296Rat
Entrez Gene: 24297Rat
Omim: 108330Human
Omim: 124060Human
SwissProt: P04798Human
SwissProt: P05177Human
SwissProt: P00184Mouse
SwissProt: P00186Mouse
SwissProt: P00185Rat
SwissProt: P04799Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.