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货号： bs-14545R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14545R-Cy3
- 英文名称
- Anti-EIF3S4/Cy3
- 中文名称
- Cy3标记的EIF3S4蛋白抗体
- 别 名
- 44kDa; Anti EIF3S4; eIF 3 delta; eIF 3 RNA binding subunit; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 delta; eIF3 p42; eIF3 p44; eIF3g; EIF3G_HUMAN; EIF3S4; EIF3S4; ; Eukaryotic translation initiation factor 3; Eukaryotic translation initiation factor 3 RNA binding subunit; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; Eukaryotic translation initiation factor 3 subunit 4 delta 44 kD; Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 subunit p42; Subunit 4 (delta 44kD); Subunit 4 delta.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human EIF3S4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.
Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Colocalizes with AIFM1 in the nucleus and perinuclear region.
Post-translational modifications:
Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Similarity:
Belongs to the eIF-3 subunit G family.
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 8666Human
Entrez Gene: 53356Mouse
Entrez Gene: 298700Rat
Entrez Gene: 393974Zebrafish
Omim: 603913Human
SwissProt: Q3ZC12Cow
SwissProt: O75821Human
SwissProt: Q9Z1D1Mouse
SwissProt: Q5RK09Rat
SwissProt: Q6DRC4Zebrafish
Unigene: 529059Human
Unigene: 427309Mouse
Unigene: 107880Rat
Unigene: 161Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.