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货号： bs-14503R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14503R-Cy3
- 英文名称
- Anti-EDF1/Cy3
- 中文名称
- Cy3标记的内皮分化相关因子1抗体
- 别 名
- CAP19; EDF-1; edf1; EDF1_HUMAN; Endothelial differentiation related factor 1; Endothelial differentiation-related factor 1; MBF1; MGC9058; Multiprotein bridging factor 1; Multiprotein-bridging factor 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转录调节因子 细胞分化 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human EDF1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Subcellular Location:
Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Tissue Specificity:
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
Post-translational modifications:
Phosphorylated (by PKA and PKC).
Similarity:
Contains 1 HTH cro/C1-type DNA-binding domain.
Database links:Entrez Gene: 8721Human
Entrez Gene: 417286Chicken
Entrez Gene: 515380Cow
Entrez Gene: 59022Mouse
Entrez Gene: 296570Rat
Omim: 605107Human
SwissProt: Q3T0V7Cow
SwissProt: O60869Human
SwissProt: Q9JMG1Mouse
SwissProt: P69736Rat
Unigene: 174050Human
Unigene: 29945Mouse
Unigene: 17092Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.