产品中心
当前位置：首页>产品中心Anti-CHTF18
货号： bs-13946R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-13946R
- 英文名称
- CHTF18
- 中文名称
- 16号染色体开放阅读框41抗体
- 别 名
- C16orf41; 6030457M03Rik; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Chromosome transmission fidelity protein 18 homolog; chtf18; Ctf18; CTF18_HUMAN; hCTF18; MGC38008; RUVBL.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 染色质和核信号 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 106kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CHTF18/C16orf41:301-400/975
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CTF18 is a 975 amino acid protein encoded by the human gene CHTF18. CTF18 is a protein that is structurally related to the Rad24 and RFC (replication factor C) proteins. CTF18 is believed to form a novel RFC complex and functions redundantly with Rad24 in the DNA replication block checkpoint. The CTF18-RFC complex is a seven-subunit structure that consists of the four small subunits of RFC, together with CTF18, DCC1, and CTF8. This RFC complex is responsible for loading the replication clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA and functions in DNA replication and repair. Regulated unloading of PCNA during the progression and termination of DNA replication does not seem to be a function of the CTF18-RFC complex.
Function:
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
Subcellular Location:
Nucleus. Associates with chromatin during S phase.
Similarity:
Belongs to the activator 1 small subunits family. CTF18 subfamily.
SWISS:
Q8WVB6
Gene ID:
63922
Database links:Entrez Gene: 63922Human
SwissProt: Q8WVB6Human
SwissProt: Q96S08Human
SwissProt: Q9BRG5Human
Unigene: 153850Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.