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货号： bs-13884R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-13884R
- 英文名称
- CHAD
- 中文名称
- 富含亮氨酸软骨蛋白抗体
- 别 名
- Cartilage leucine rich protein; Cartilage leucine-rich protein; Chad; CHAD_HUMAN; Chondroadherin; Chondroadherin proteoglycan; SLRR4A.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 细胞粘附分子 细胞外基质
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CHAD:281-359/359
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CHAD is implicated in the adhesion of fibroblasts, osteoblasts and chondrocytes, which is mediated by interactions with Integrin α2/β1. Existing primarily in monomeric form, CHAD is a secreted protein that localizes to the extracellular matrix and belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily. CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events.
Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation.
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Tissue Specificity:
Present in chondrocytes at all ages.
Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
SWISS:
O15335
Gene ID:
1101
Database links:Entrez Gene: 1101Human
Entrez Gene: 281069Cow
Entrez Gene: 609296Dog
Entrez Gene: 12643Mouse
Entrez Gene: 29195Rat
Omim: 602178Human
SwissProt: Q27972Cow
SwissProt: O15335Human
SwissProt: O55226Mouse
SwissProt: O70210Rat
Unigene: 97220Human
Unigene: 440523Mouse
Unigene: 9899Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.