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货号： bs-15466R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-15466R
- 英文名称
- HERV-FRD
- 中文名称
- 人内源性逆转录病毒膜糖蛋白2抗体
- 别 名
- EFRD1_HUMAN; Endogenous retrovirus group FRD member 1; Envelope polyprotein; ERVFRD-1; FLJ41944; FLJ90611; GLLL6191; HERV FRD 6p24.1 provirus ancestral Env polyprotein; HERV FRD; HERV FRD provirus ancestral Env polyprotein; HERV-FRD; HERVFRD; HERVFRD provirus ancestral Env polyprotein; MGC87585; SU; Syncytin 2; Syncytin B; Syncytin-2; TM; Transmembrane protein; UNQ6191;
- Specific References (1) | bs-15466R has been referenced in 1 publications.[IF=4.43] Díaz-Carballo, David, et al. "Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements." Journal of Experimental & Clinical Cancer Research 34.1 (2015): 81. WB ; Human.PubMed:26260344
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 细菌及病毒
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21/37/58kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HERV-FRD :331-430/538
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.
SU mediates receptor recognition (By similarity).
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
Subunit:
The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).
Subcellular Location:
Virion.
Transmembrane protein: Cell membrane; Single-pass membrane protein (Potential).
Tissue Specificity:
Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
Post-translational modifications:
Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity).
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).
Similarity:
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
SWISS:
P60508
Gene ID:
2086
Database links:Entrez Gene: 2086 Human
SwissProt: P60507 Human
SwissProt: P60508 Human
SwissProt: P61550 Human
SwissProt: P61565 Human
SwissProt: P61566 Human
SwissProt: P61567 Human
SwissProt: P61570 Human
SwissProt: Q14264 Human
SwissProt: Q69384 Human
SwissProt: Q902F8 Human
SwissProt: Q902F9 Human
SwissProt: Q96L62 Human
SwissProt: Q9N2J8 Human
SwissProt: Q9N2J9 Human
SwissProt: Q9N2K0 Human
SwissProt: Q9NX77 Human
SwissProt: Q9UKH3 Human
SwissProt: Q9UQF0 Human
Unigene: 250693 Human
Unigene: 406976 Human
Unigene: 631996 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.