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货号： bs-2353R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2353R
- 英文名称
- Mast Cell Chymase
- 中文名称
- 肥大细胞类糜蛋白酶1抗体
- 别 名
- CHYMASE; Alpha-chymase; Chymase 1; Chymase 1 mast cell; Chymase; Chymase, heart; Chymase, mast cell; CMA1; CMA1_HUMAN; CYH; CYM; EC 3.4.21.39; Mast cell chymase 1; Mast cell protease 3; Mast cell protease 5; Mast cell protease I; Mast cell protease III; Mcp-5; MCP3P; Mcpt5; MCT1; MGC119890; MGC119891; MMCP-5.
- Specific References (5) | bs-2353R has been referenced in 5 publications.[IF=3.73] Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, et al. (2013) Characterization of the Cardiac Renin Angiotensin System in Oophorectomized and Estrogen-Replete mRen2.Lewis Rats. PLoS ONE 8(10):e76992. WB ; Rat.PubMed:24204720[IF=3.73] Zheng J, Wei C-C, Hase N, Shi K, Killingsworth CR, et al. (2014) Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog. PLoS ONE 9(4): e94732. IHC-P ; Dog.PubMed:24733352[IF=2.28] Zhao, Zhuo, et al. "GPR30 Decreases Cardiac Chymase/Angiotensin II by Inhibiting Local Mast Cell Number." Biochemical and Biophysical Research Communications (2015). WB, IHC-P ; Rat.PubMed:25712524[IF=3.23] Sansoè, Giovanni, et al. "Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data." PLOS ONE11.9 (2016): e0162644. IHC-P ; Human, Rat.PubMed:27637026[IF=11.33] Moretti, Silvia, et al. "A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis." Nature Communications 8 (2017): 14017. IHC-P ; Mouse.PubMed:28090087
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 心血管 细胞生物 免疫学 信号转导 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Sheep, Guinea Pig,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 细胞定位
- 细胞浆 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Mast Cell Chymase:28-42/247
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
Function:
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Subcellular Location:
Secreted. Cytoplasmic granule. Note=Mast cell granules.
Tissue Specificity:
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
Similarity:
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
SWISS:
P23946
Gene ID:
1215
Database links:Entrez Gene: 1215 Human
Entrez Gene: 17228 Mouse
Omim: 118938 Human
SwissProt: P23946 Human
SwissProt:P21844 Mouse
Unigene:135626 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-alpha smooth muscle Actin (bs-10196R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 32 kD
Observed band size: 52 kD
Sample:
Lung (Mouse) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti- Mast Cell Chymase (bs-2353R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 23 kD
Blank control: H9C2 cells.
Isotype Control Antibody: Rabbit IgG-PE ; Primary Antibody Dilution: 1μg in 100 1μL 1X PBS containing 0.5% BSA.