产品中心
当前位置：首页>产品中心Anti-Phospho-Tyk2(Tyr1054 + Tyr1055)
货号： bs-3437R 基本售价： 1580.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3437R
- 英文名称
- Phospho-Tyk2 (Tyr1054 + Tyr1055)
- 中文名称
- 磷酸化非受体酪氨酸蛋白激酶2抗体
- 别 名
- TYK2 (phospho Y1054 + Y1055); TYK2(Phospho-Tyr1054/1055); Tyk2(phospho Y1054/1055); TYK2 (phospho Tyr1054/1055); p-TYK2 (Tyr1054/1055); JTK 1; JTK1; TYK 2; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Protein Tyrosine Kinase 2; Tyrosine kinase 2; TYK2_HUMAN; Non-receptor tyrosine-protein kinase TYK2.
- 规格价格
- 100ul/1580元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 134kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human Tyk2 around the phosphorylation site of Tyr1054/1055:HE(p-Y)(p-Y)RV
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
Function:
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Subunit:
Interacts with JAKMIP1.
Tissue Specificity:
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
DISEASE:
Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.
SWISS:
P29597
Gene ID:
7297
Database links:Entrez Gene: 7297 Human
Entrez Gene: 54721 Mouse
Entrez Gene: 100361294 Rat
Omim: 176941 Human
SwissProt: P29597 Human
SwissProt: Q9R117 Mouse
Unigene: 75516 Human
Unigene: 20249 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
A549(Human) Cell Lysate at 30 ug
Primary: Anti-Phospho-Tyk2(Tyr1054 + Tyr1055) (bs-3437R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 134 kD
Observed band size: 134 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (Phospho-Tyk2(Tyr1054 + Tyr1055)) Polyclonal Antibody, Unconjugated (bs-3437R) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (Phospho-Tyk2(Tyr1054 + Tyr1055)) Polyclonal Antibody, Unconjugated (bs-3437R) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.