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货号： bs-13225R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-13225R
- 英文名称
- FUBP3
- 中文名称
- 远端上游元件结合蛋白3抗体
- 别 名
- Far upstream element (FUSE) binding protein 3; Far upstream element binding protein 3; Far upstream element-binding protein 3; FBP3; FLJ25229; FUBP 3; FUBP3; FUBP3_HUMAN; FUSE binding protein 3; FUSE-binding protein 3; OTTHUMP00000022369.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转录调节因子 细胞分化 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 62kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FUBP3:21-120/572
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Activation of FUSE, the far-upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or Far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in a number of cell lines.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 4 KH domains.
SWISS:
Q96I24
Gene ID:
8939
Database links:Entrez Gene: 8939 Human
Entrez Gene: 320267 Mouse
Entrez Gene: 362106 Rat
Omim: 603536 Human
SwissProt: Q96I24 Human
Unigene: 673029 Human
Unigene: 98751 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.